Genetic Polymorphism in Subjects with Type 2 Diabetes and Longitudinal Analysis of Renal Function: “SURDIAGENE” Study (SUivi Rénal , DIAbète de type 2 et GENEtique) FRESH-PEF4071-en Pierre-Jean SAULNIER Genetic Polymorphism in Subjects with Type 2 Diabetes and Longitudinal Analysis of Renal Function: “SURDIAGENE” Study (SUivi Rénal , DIAbète de type 2 et GENEtique) SURDIAGENE FRESH-PEF4071-en 4071 FRESH-PEF4071 Michèle GROSDENIER CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS Epidemiology France Portal (PEF) GROUPT ETUDE MALADIES METABOLIQUES SYST. (GEMMS) MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES null Samy;HADJADJ Michèle;GROSDENIER Health episodes renal function cardiovascular death population health system Endocrinology Nephrology Type 2 diabetes mellitus Biological determinants: Genetic predisposition Healthcare system determinants: Use of care Behavioral determinants: Eating habits Biological determinants Healthcare system determinants Behavioral determinants MAIN: to investigate the genetic determinants associated with changes in renal function (changes in creatinine clearance) SECONDARY: 1. - to investigate the genetic determinants associated with changes in urinary albumin excretion 2 - to investigate the genetic determinants associated with other degenerative complications of diabetes (retinopathy, cardiovascular events) null France Individuals Patients population Male Female Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) B1. Type 2 diabetes (T2D): Subjects from the SURDIAGENE study with T2D. The distinction between type 1 (TD1) and type 2 (T2D) diabetes is sometimes difficult. We define criteria for T2D diagnosis as: - age at diagnosis is 35 years old or over - apparent insulin-dependence after more than 2 years following diabetes diagnosis - absence of secondary diabetes - absence of ketonuria at diagnosis B2: Longitudinal follow-up: Subjects in the SURDIAGENE study with T2D who are being monitored for diabetes for at least one year, which includes a collection of clinical (blood pressure, weight) and biological data (glycated haemoglobin, serum creatinine, urinary albumin excretion) to analyse the progression of renal disease and other degenerative (retinal and cardiovascular) complications B3. Exclusion criteria is defined as: Subjects who are not permitted to participate in the SURDIAGENE study are subjects who a) fulfil medical criteria for exclusion - do not have diabetes or have T1D or secondary diabetes - are presenting renal disease caused by non-diabetic renal insufficiency (arterial hypertension is not considered as part of the exclusion criteria, except if hypertensive nephropathy precedes discovery of diabetes). - proteinuria at time of diabetes diagnosis - non-diabetic glomerular nephropathy confirmed by renal biopsy - pure vascular nephropathy - confirmed glomerular haematuria or malformed uropathy - chronic interstitial nephritis with history of pyelonephritis or persistent urinary tract infections - follow-up is less than 1 year b) fulfilling legal (amended law dated 20th December 1988) - minors - adults protected by law - deprived of liberty - brain-dead - who have not given their written participation consent - women who are pregnant, parturient or breastfeeding - not affiliated to social security Clinical data Biological data Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1200 Unknown Restricted access Send request to scientist in charge Access on specific project only