Genetic Polymorphism in Subjects with Type 2 Diabetes and Diabetic Nephropathy: Study “DIAB’2-NEPHRO-GENE” (DIABète de type 2, NEPHROpathie et GENEtique) FRESH-PEF3956-en Pierre-Jean SAULNIER Genetic Polymorphism in Subjects with Type 2 Diabetes and Diabetic Nephropathy: Study “DIAB’2-NEPHRO-GENE” (DIABète de type 2, NEPHROpathie et GENEtique) D2NG FRESH-PEF3956-en 3956 FRESH-PEF3956 Michèle GROSDENIER CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS Epidemiology France Portal (PEF) AGENCE FRANCAISE DE DEVELOPPEMENT (AFD) GROUPT ETUDE MALADIES METABOLIQUES SYST. (GEMMS) MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES SOCIETE FRANCOPHONE DU DIABETE null Samy;HADJADJ Michèle;GROSDENIER Endocrinology Nephrology Type 2 diabetes mellitus Biological determinants: Genetic predisposition Healthcare system determinants: Use of care Behavioral determinants: Eating habits Biological determinants Healthcare system determinants Behavioral determinants MAIN: to study the genetic determinants associated with renal complications from Type 2 diabetes using a triple-integrated approach: *Association Study *Cross-population Study *Liaison Study SECONDARY: 1 - to investigate diabetic nephropathy specific phenotypes (anatomopathological criteria) 2 - to complete case-control analysis with a longitudinal follow-up study (SURDIAGENE project) null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Individuals included in the study are adult subjects who have given their signed informed consent and covered by a social security scheme or registered with a likewise scheme. We wish to include different subjects with type 2 diabetes in the DIAB2-NEPHRO-GENE study that can be divided into three groups: 1 - Case-control subjects (with no diabetic nephropathy) - subjects with diabetic retinopathy, regardless of stage - known type 2 diabetes for more than 5 years - normal urinary albumin excretion (UAE) (defined as urinary albumin concentration strictly below 20 mg/l or 30 mg/24h), twice occurring out of 3 consecutive samples over the last 5 years. - Normal UAE in the absence of conversion enzyme inhibitor or angiotensin II antagonist receptors - creatinine strictly less than 150M.2 - Case subjects (with diabetic nephropathy): - subjects with diabetic glomerulopathy confirmed by renal biopsy, even with absence of retinopathy - or subjects with the following characteristics: - diabetic retinopathy regardless of stage. - known type 2 diabetes for more than 5 years - abnormal urinary albumin excretion (UAE)(defined as urinary albumin concentration higher or equal to 20 mg/l or 30 mg/24h), twice occurring out of 3 consecutive samples over the last 5 years - with or without change to renal function (defined by creatinine higher than 150 µmol/l, or need for extra-renal purification or renal transplantation). - absence of kidney disease other than diabetic nephropathy 3 - known type 2 diabetes for at least 5 years (recent diabetes) regardless of urinary albumin excretion or creatinine Clinical data Biological data Health event/morbidity Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Converting or copying information into a structured record Observational Study Observational Study Case-control study - 1100 cas/cases- 660 témoins/controls Completed study Restricted access Send request to the scientist in charge Access on specific project only