Epidemiological study on low gestational age infants 2 FRESH-PEF3411-en Pierre-Yves ANCEL Epidemiological study on low gestational age infants 2 EPIPAGE 2 FRESH-PEF3411-en 3411 FRESH-PEF3411 Pierre-Yves ANCEL INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) null Pierre-Yves;ANCEL Perinatality neonatal mortality and morbidity (respiratory neurological infectious metabolic) neural development (motor sensory cognitive) growth) handicaps Gynaecology and obstetrics Paediatrics Biological determinants: Genetic predisposition Biological determinants More than 10 years are passed since the beginning of the EPIPAGE study. The evolutions occurred since justify the creation of a new cohort. The main objectives of EPIPAGE 2 are: 1) Study the becoming of extremely premature children and their families 2) The evaluation of care organization effects and medical practice on premature children’s health and development 3) Research of causes and consequences of prematurity 4) Study the path of the different families and the decisions process at the moment of birth and intensive care 5) The needs analysis of medical and educational care One of the originalities of the study is to have permitted the creation of complementary and multidisciplinary projects, in order to reply and deepen to question difficult to handle on the children of the cohort. These projects, based on the same structure of EPIPAGE 2, needs additional investigations and an own funding. A total of 8 studies have been developed in the field of brain imaging, bio-markers, nutrition, mother-child interaction and ethics: - ETHIQUE (decision process leading to survival or death of children born between 22 and 26 weeks of amenorrhea) - EPIFLORE (study of the introduction of the intestinal microbiota) - EPIRMEX (Study of the executive functions and of the language development, depending on anomalies detected through NRM) - BIOPAG (Identification of the early bio-markers of pathologies from an umbilical cord sample (DNA, RNA) - OLIMPE (Study of the existing links between the quality of early mother-child interactions and the neural and developmental becoming) - CHORHIST (Research of chorioamniontides through anatomo-pathological analysis of placenta) - EPINUTRI (Study of the associations of the intake of polyunsaturated fatty acids, iron intake and neurological becoming of extremely premature children) - EPIPAIN 2 (treatment of painful movements in neonatal intensive care. RE-CO-NAI platform EPIPAGE 2 is one of the two cohorts constituting the RE-CO-NAI platform, together with the ELFE cohort. The general objective of this platform is to create an infrastructure offering the measures required for collecting, highly secured storage and distribution of data concerning the pregnancy, the birth and the child. The research platform consist of cohorts of infants followed since birth will allow to study, in a global and multidisciplinary way, the stakes on health, development and socialization of children. It will in addition provide substantial visibility in the world of academic research (French and international), but also with regards to bodies, associations, and industries that have interests in children. As such, it will allow for an optimized valorization of the data collected and will facilitate the dissemination of data. null France Individuals General population Male Female Infant, Newborn (birth to 28 days) Infant (28 days to 2 years) Child, Preschool (2 to 5 years) Child (6 to 12 years) EPIPAGE 2 is a population based perspective cohort. All the children born in 25 regions of France, extremely premature (22-26 weeks of amenorrhea) on 8 months, highly premature (27-31 weeks of amenorrhea) on 6 months and moderately premature (32-34 weeks of amenorrhea) on 1 month. A control group of full-born children will be constituted from Elfe study. Children of families having expressed a refusal will not be included. In this case, the information from the health certificate of the 8th day could be used to characterize the population concerned. Clinical data Participant-reported health data Biological data Coherence request during and after computer data entry. Missing data checked back to the original file. Subjects an doctors remainders for follow-up visits. Internal quality audit report. Patients receive information about the use of their data. Health event/morbidity Health event/mortality Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Psychological tests/clinical scales (depression, cognition, quality of life, etc.) Observational Study Observational Study Cohort study - 8398 prématurés/premature births and Induced therapeutic abortions/avortements - 7595 enfants/children Unknown Restricted access Data utilization possible for academic teams. Access to every interested research team after an evaluation of the project by the scientific council Access on specific project only