Case-Control Study on the Relationship Between Environmental, Domestic and Occupational Exposure during Early Life, and the Risk of Germ Cell Testicular Cancer in Adulthood FRESH-PEF33513-en Béatrice FERVERS Case-Control Study on the Relationship Between Environmental, Domestic and Occupational Exposure during Early Life, and the Risk of Germ Cell Testicular Cancer in Adulthood TESTIS FRESH-PEF33513-en 33513 FRESH-PEF33513 Olivia PEROL Béatrice FERVERS Rémi BERANGER CENTRE LEON BERARD Epidemiology France Portal (PEF) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) INSTITUT NATIONAL DU CANCER (INCA) null Olivia;PEROL Béatrice;FERVERS Rémi;BERANGER multiple exposure endocrine disruptors environment pesticides risk factors Oncology Environmental determinants: Climate Biological determinants: Genetic predisposition Environmental determinants: Other Behavioral determinants Socio-demographic and economic determinants: Employment Environmental determinants Biological determinants Socio-demographic and economic determinants Main aim: To study the relationship between various exposures, especially to pesticides, during critically sensitive periods in testicular development (pre-conception, intrauterine and early childhood) and the risk of developing testicular cancer in adulthood. Environmental, occupational and domestic exposure will be taken into account in this assessment. Secondary objectives: To investigate the hypothesis of a dual impact (early life and adulthood) by studying the relationship between various exposures (occupational, environmental and domestic) until adulthood and the risk of developing testicular cancer. To study genetic polymorphisms that may be potentially related to TGCT in the literature, as well as the interactions between these polymorphisms and environmental risk factors, including polymorphisms linked to the metabolic pathways of organochlorine pesticides. null France Individuals General population Male Young Adult (19 to 24 years) Adult (25 to 44 years) Inclusion criteria: Case subjects and controls must meet the following criteria to be included: – Males aged between 18 and 44 – Born in metropolitan France – Can understand, read and write French – No psychiatric illness or severe cognitive disorder – Volunteered for the study and signed an informed consent – Member of a social security scheme. – Males under temporary guardianship– History of TGCT or cryptorchidism (only for controls). Participant-reported health data Biological data Health event/morbidity Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Interview with the participant (including clinical) Observational Study Observational Study Case-control study 1,500 subjects – 500 cases – 1,000 controls Unknown Restricted access Contact the principal investigator Access on specific project only