Relationship between insulin sensitivity and cardiovascular disease FRESH-PEF3301-en Beverley BALKAU Relationship between insulin sensitivity and cardiovascular disease EGIR-RISC FRESH-PEF3301-en 3301 FRESH-PEF3301 Beverley BALKAU CTRE RECHERCHE NUTRITION HUMAINE RHONE-ALPES (CRNH RHONE-ALPES) Epidemiology France Portal (PEF) EUROPEAN COMMISSION RESEARCH ASTRAZENECA (FRANCE) MERCK SANTE null Endocrinology Behavioral determinants Socio-demographic and economic determinants Behavioral determinants: Addiction Main objective: study of insulin resistance and atherosclerosis, determinants of insulin resistance, its evolution on 9 years and consequences, diabetes, cardiovascular diseases and premature death. Secondary objectives: 1. The evaluation of insulin resistance and its association with cardiovascular diseases 2. Identification of genetic and environmental factors linked to insulin resistance 3. The proposition of a model to identify insulin resistance null Austria Denmark Finland France Germany Greece Netherlands Ireland Italy Sweden Spain Switzerland United Kingdom Serbia Montenegro Individuals Patients population Male Female Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged between 30 and 60 years - Good general health condition - No symptoms of cardiovascular diseases - blood pressure inferior to 170/90 mm Hg - Total cholesterol inferior to 7,8 mmol/l - Triglycerides levels inferior to 4,6 mmol/l - Plasma glucose level (on an empty stomach and 2 hours after an oral glucose control) inferior to 7,0/11,1 mmol/l - No treatment related to diabetes, hypertension or lipid disorders Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1500 Unknown Restricted access For data access, please submit a written request to the "project management board". Access on specific project only