Study on Long-Term Outcome for Subjects Cured of Childhood Cancer and Adolescents Diagnosed Before 2000 in France FRESH-PEF3229-en Florent DE VATHAIRE Study on Long-Term Outcome for Subjects Cured of Childhood Cancer and Adolescents Diagnosed Before 2000 in France FCCSS FRESH-PEF3229-en 3229 FRESH-PEF3229 Florent DE VATHAIRE Carole RUBINO INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) null Florent;DE VATHAIRE Carole;RUBINO iatrogenic effects social integration radiology radiotherapy chemotherapy quality of life France mortality cohort solid cancer in childhood and adolescence subsequent cerebrovascular and cardiovascular diseases survivors risk factors of iatrogenic pathologies dosimetric reconstruction second cancer Socio-demographic and economic determinants: Employment Behavioral determinants Biological determinants: Genetic predisposition Socio-demographic and economic determinants Healthcare system determinants: Use of care Behavioral determinants: Addiction Biological determinants Healthcare system determinants The main objective of the study is to improve knowledge about the long-term health and social outcomes for children and adults cured of cancer. The FCCSS particularly focuses on: - Estimating the incidence of iatrogenic diseases occurring after long-term treatment of a childhood tumour; - Identifying and quantifying risk factors associated with these diseases in order to reduce iatrogenic risks and customise treatment; - Identifying clinical markers of the progression of these diseases in order to improve early diagnosis and treatment - Implementing customised follow-up consultations and the preventative actions required. This study was implemented in order to increase knowledge on the long-term social and health implications of cancer treatment received during childhood. The FCCSS follows the Euro2K study, which showed that survivors of childhood cancer are at a significantly high risk of serious iatrogenic events (e.g. long-term mortality, second cancer, diabetes, cardiac diseases, and cerebrovascular disease). null France Individuals Patients population Male Female Infant, Newborn (birth to 28 days) Infant (28 days to 2 years) Child, Preschool (2 to 5 years) Child (6 to 12 years) Subjects under 21 years old diagnosed with cancer before 2000 in France. Clinical data Participant-reported health data Biological data Socio-demographic data Paraclinical data (non-biological) : Imaging International Classification of Diseases (ICD-O ICD-9 ICD-10); DCI INSEE municipality and country codes. Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception Others Other Through organizations (health services or institutions schools businesses etc.) [10000-20000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study - 4,500 (1942-1985) - Euro2K - 10,000 (2000) - 16,000 (2014). Unknown Restricted access The use of anonymised data on the outcome of children cured of cancer from the top 5 cancer centers is possible for any research by a team with proven experience in the field of expertise. Usage is determined on a case-by-case and is governed by an agreement. The use of anonymised FCCSS data shall be possible for any external research team involvong the outcome of children cured of cancer and shall be determined on a case-by-case basis following submission of the project to the cohort scientific committee. Participants from paediatric oncology departments will have access to their patients' data. Access on specific project only