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  <citation>
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<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                French Cohort of Three Major Psychiatric disorders: Schizophrenia, Bipolar disorders, and Asperger syndrome            </titl>
      <altTitl>
                    Psy-COH                </altTitl>
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                FRESH-PEF3145-en            </IDNo>
      <IDNo agency="PEF">
                    3145                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF3145                </IDNo>
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                    Marion LEBOYER                                                                                                                                        <ExtLink title="ORCID" URI="0000-0001-5473-3697" role="pi id"/>
                                                                                                                    <ExtLink title="IdRef" URI="089352475" role="pi id"/>
                                                        </AuthEnty>
      <AuthEnty affiliation="UNIVERSITE PARIS EST CRETEIL VAL DE MARNE (UPEC)">
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      <producer role="sponsor">
                                            UNIVERSITE SORBONNE PARIS NORD                                            <ExtLink title="ROR" URI="https://ror.org/0199hds37" role="sponsor id"/>
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                                            UNIVERSITE PARIS EST CRETEIL VAL DE MARNE (UPEC)                                            <ExtLink title="ROR" URI="https://ror.org/05ggc9x40" role="sponsor id"/>
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                Epidemiology France Portal (PEF)            </prodPlac>
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                                            AGENCE NATIONALE DE LA RECHERCHE (ANR)                                            <ExtLink title="ROR" URI="https://ror.org/00rbzpz17"/>
                                            <ExtLink title="SIREN" URI="130002504"/>
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      <fundAg>
                                            SANOFI (FRANCE)                                            <ExtLink title="ROR" URI="https://ror.org/02n6c9837"/>
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    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="UNIVERSITE PARIS EST CRETEIL VAL DE MARNE (UPEC)" email="marion.leboyer@inserm.fr">
                    Marion;LEBOYER
                                            <ExtLink title="ROR" URI="https://ror.org/05ggc9x40" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="199411117" role="organisation id"/>
                                    </contact>
      <depDate date="2026-10-17"/>
      <distDate date="2026-10-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <studyAuthorization>
    <authorizingAgency>CNIL                </authorizingAgency>
  </studyAuthorization>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <topcClas vocab="health theme">
                        Psychiatry                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/3de50dee-da1c-4791-a386-56bca24a5fed"/>
                                                            <ExtLink title="MeSH" URI="D011570"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Addiction medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/42d645e0-f58d-40ed-9917-5b227ff41a92"/>
                                                            <ExtLink title="MeSH" URI="D000073316"/>
                                                </topcClas>
      <topcClas vocab="cim-11">
                        Schizophrenia                                            </topcClas>
      <topcClas vocab="cim-11">
                        Bipolar or related disorders                                            </topcClas>
      <topcClas vocab="cim-11">
                        Autism spectrum disorder                                            </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants: Use of care                    </topcClas>
      <topcClas vocab="health determinant">
                        Biological determinants: Genetic predisposition                    </topcClas>
      <topcClas vocab="health determinant">
                        Environmental determinants: Other                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Socio-demographic and economic determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants: Addiction                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Biological determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Environmental determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">1. Improve our ability to offer early diagnosis and prevention through identification of valid biomarkers/ bio-signatures of three major mental disorders 2. Identify trajectories of patients moving across stages of disorder and behavioural indicators and biomarkers predecting risk and prognosis 3. Estimate utilization of services, healthcare, societal costs and quality of life of patients suffering from these three disorders 4. Allow national and international academic collaborators or industry partners to access cohort or data collected, to accelerate scientific progress.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2012-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Adolescent (13 to 18 years)                                                            <concept vocab="MeSH" vocabURI="D000293"/>
                                                    </universe>
      <universe level="age" clusion="I">Young Adult (19 to 24 years)                                                            <concept vocab="MeSH" vocabURI="D055815"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="D008875"/>
                                                    </universe>
      <universe clusion="I">Young patients -between 16 and 35 years old - with psychotic disorders (bipolar disorders dans schizophrenia), focussing on first-episodes, as well as neuro-developmental disorders (autism without mental retardation, or Aspeger, aged 3 years and upwards)                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Paraclinical data (non-biological)</dataKind>
      <dataKind>Paraclinical data (non-biological) : Imaging</dataKind>
      <dataKind>Biological data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity
Health care consumption and services
Quality of life/health perception</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>[1000-10000[ individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Psychological tests/clinical scales (depression, cognition, quality of life, etc.)                                                            <concept vocab="CESSDA" vocabURI="MeasurementsAndTests.Psychological"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <anlyInfo>
      <respRate>We aim to recruit 1000 bipolar, 800 schizophrenic, and 200 Asperger patients.</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Restricted access                                                    </avlStatus>
    </setAvail>
    <useStmt>
      <conditions>Psy-COH will allow data access to academic as well as industrial partners, thus giving birth to numerous innotiative projects</conditions>
    </useStmt>
  </dataAccs>
  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
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<dataDscr>
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