Chronic Kidney Disease - Renal Epidemiology and Information Network FRESH-PEF3087-en Bénédicte STENGEL Chronic Kidney Disease - Renal Epidemiology and Information Network CKD-REIN FRESH-PEF3087-en 3087 FRESH-PEF3087 Bénédicte STENGEL INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) UNIVERSITE LYON 3 JEAN MOULIN CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE NANCY ETABLISSEMENT FRANCAIS DU SANG (EFS) UNIVERSITE PARIS-SACLAY AGENCE DE LA BIOMEDECINE UNIVERSITE CLAUDE BERNARD LYON 1 CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX CENTRE HOSPITALIER UNIVERSITAIRE AMIENS-PICARDIE COMMISSARIAT A L&#039; ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (CEA) INSTITUT PASTEUR DE LILLE Arbor Research Collaborative for Health Epidemiology France Portal (PEF) null Elodie;SPEYER Bénédicte;STENGEL organization of care and cost-effectiveness of practices Dialysis quality of life biomarkers Nephrology Chronic kidney disease Socio-demographic and economic determinants Biological determinants: Genetic predisposition Behavioral determinants Behavioral determinants: Eating habits Healthcare system determinants: Use of care Biological determinants Healthcare system determinants The CKD-REIN cohort will provide a research platform to address key questions regarding a number of determinants and biomarkers associated with adverse CKD outcomes and to assess clinical practices and costs in patients selected at random from a representative sample of various types of nephrology consultations. In addition, it will meet the objectives of the starting international CKD Outcomes and Practice Patterns Study (CKDopps) designed principally to identify best treatment practices in patients with advanced CKD in several countries, including France. The objectives of the CKD-REIN study are: (1) to study a set of social, environmental, behavioral, clinical, and genetic factors, and their interactions in relation with the outcomes of CKD and its complications, including progression to ESRD and mortality, as well as the onset of several relevant acute and chronic clinical events : acute kidney injury, infections; cardiovascular diseases, cognitive decline, bone disease, and cancer ; (2) to assess several new biomarkers to predict adverse outcomes of CKD and its complications; (3) to evaluate the associations of provider practices (management of hypertension and of CKD complications such as anemia, nutritional abnormalities, and bone mineral disorder; timing of dialysis initiation and transplant wait-listing) with achievement of clinical practice guidelines, clinical outcomes (survival, ESRD, hospital admissions) and patient-reported outcomes (QoL, satisfaction). (4) to evaluate the associations of health care organization (e.g., multidisciplinary team, care network) and clinic services (e.g., for nutrition, educational programs) with clinical and patient-reported outcomes, and achievement of clinical practice guidelines; (5) to estimate the relative cost-effectiveness of different provider practices and clinic services. (6) to estimate the CKD incidence and prevalence in nephrology healthcare practices in France, depending on age, sex, social status, diabetes status, and depending on the stage and type of CKD. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Study eligibility requires an eGFR < 60 mL/min/1.73 m2 for at least one month and no prior dialysis or transplantation. Inclusion criteria also requires less than 3 years of follow-up by the nephrology clinic for patients with CKD stage 3 in order to reduce survival bias due to prevalent cases. Patients <18 yrs old, pregnant, institutionalized, or unable to give inform consent are excluded, as well as patients who decline to participate. , as well as patients who decline to participate. Clinical data Participant-reported health data Biological data Socio-demographic data CKD-REIN biobank received a bio-collection authorization from the French Ministry of Research CODECOH n° AC-2012-1624 based on the Picardie Biobank quality standard Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Medico-administrative database Observational Study Observational Study Cohort study 3033 patients Unknown Restricted access Accessibility of the database will be determined case by case by the governing board in agreement with the scientific committee. The IP and contractual issues will be examined by Inserm Transfert. Special attention will be paid on confidentiality, ethical issues and on the use of the biobank to yield the greatest scientific value to the community and avoid depletion of this finite resource. Data collected about CKD patients, their sociodemographic characteristics, their environment and their treatments, the organization of health care system based on a representative sample of providers in the field of CKD, and the biobank will provide a unique research platform of major interest for a number of public and private organizations involved in the field of CKD research and patient care. CKD-REIN will encourage innovative projects and broad use of these data by external research groups or firms. Access on specific project only