Follow-up of the participants to an intervention controlled trial for the primary prevention of type-2 diabetes mellitus and metabolic syndrome on Reunion Island FRESH-PEF20903-en Adrian FIANU Follow-up of the participants to an intervention controlled trial for the primary prevention of type-2 diabetes mellitus and metabolic syndrome on Reunion Island REDIA-prev1 Cohort FRESH-PEF20903-en 20903 FRESH-PEF20903 François FAVIER Adrian FIANU INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) AGENCE NATIONALE DE LA RECHERCHE (ANR) CENTRE HOSPITALIER UNIVERSITAIRE DE LA REUNION INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) SANTE PUBLIQUE FRANCE null François;FAVIER Adrian;FIANU adiposity lifestyle intervention vulnerable population physical activity glycemic status quasi-experimentation diet community approach primary prevention post-trial follow-up study long-term effectiveness transferability. Endocrinology Type 2 diabetes mellitus Behavioral determinants Behavioral determinants: Eating habits Primary objective: to evaluate the long-term effectiveness of an intervention promoting a healthy diet and the practice of a moderate regular physical activity, on body weight and adiposity (waist circumference, fat mass), in Type-2 diabetes mellitus (T2DM) high-risk young adults. Secondary objectives: - To compare body weight change and adiposity change between groups (intervention versus control) in the entire cohort including all screened persons (with high-risk status or not). - To compare diet and physical activity reported at follow-up, between groups, then according to the intervention adherence. - To compare incidence of screened glycemic impairments between groups and according to the baseline risk level. - To describe change in knowledge and beliefs on both T2DM and obesity (KABP). null France La Réunion Individuals General population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) The target population eligible to the lifestyle intervention trial was composed of men and women (non-pregnant), aged 18-40, with no serious illness (e.g., diabetes, cardiovascular disease, cancer) nor disability (incompatible with physical activity practice), living in the studied districts, and screened at home as high-risk subjects. This high-risk status was based on a combination of T2DM risk factors: overall obesity (BMI >= 30 kg/m²), or central adiposity (waist circumference >= 100 cm for men, >= 90 cm for women), or overweight status (BMI between 25 and 30 kg/m²) associated with at least one other T2DM risk factor *. * High blood pressure treated or detected (>= 140/90 mm Hg), elevated glycated hemoglobin (HbA1c between 5.5% and 6.0%), family history of diabetes at first degree, and for women, having a child weighting more than 4 kg at birth and /or an history of gestational diabetes. Screened subjects without high-risk status were thus not obese (and if overweight with no other T2DM risk factors from those listed above). These collateral persons had been included in the follow-up process besides the high-risk subjects, but they did not participate to the long-term effectiveness evaluation analysis (primary objective of this research). All subjects were screened as non-diabetic based on glycated hemoglobin (HbA1c) measure < 6.0% Clinical data Participant-reported health data Biological data Socio-demographic data BMI: body mass index WHO cut-off for adults. Items of the physical activity questionnaire of Baecke et al. Am J Clin Nutr 1982. Food consumption: estimation of food servings photo album INSERM E3N team. PCS (professions and professional categories): INSEE nomenclature. Recalling of subjects for follow-up visits information on personal data use. - Monitoring by a clinical research associate selected by the sponsor: after the first subject’s inclusion regularly according to the follow-up implementation and the observed protocol\'s deviations at the end of the study. - Audit / inspection: at each step of the study and until 15 years after study completion. A inter CIC\'s Audit was conducted by the INSERM Institut thématique Santé Publique Pôle Recherche Clinique in 2011 November. - Use of a consistency query: at the time of data entry. - Missing data management: when necessary use of subject contact for data completion in the closest timeframe. - Data management implementation before statistical analysis. Health event/morbidity Others Non-probability: Purposive or "judgement" sampling Population database for statistical purposes [1000-10000[ individuals Educational tests/assessment of health knowledge (literacy, self-management, interpretation of medical information, etc.) Observational Study Observational Study Cohort study At inclusion:- 1251 screened persons. - 445 high-risk persons. *- 806 collateral persons screened without "high-risk" status. * The short-term effectiveness of the lifestype intervention was evaluate on a total of 439 high-risk subjects (see: Favier et al. Rev Med Ass Maladie 2005). However, six non eligible persons had participated to the intervention: 4 collateral individuals (without high-risk status), plus two high-risk individuals aged 41 and 45 respectively. Although these participants were excluded from the short-term effectiveness analysis according to population selection criteria, we decided to include them in the follow-up process and to classified them in the intervention group to follow the intention-to-treat principle in the analysis of the long-term effectiveness of the lifestyle intervention, leading to 445 high-risk subjects included in the REDIA-prev1 Cohort Study. Unknown To be defined Access on specific project only