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<docDscr>
  <citation>
    <titlStmt>
      <titl>Descriptive pharmaco-epidemiological study on the use of Symbicort® Turbuhaler® in the treatment of asthma in France and impact of a new treatment strategy on compliance and asthma control</titl>
      <IDNo>FRESH-PEF188-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="GCS INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE (GCS ICANS)" role="">Pascal PIEDBOIS</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
</docDscr>
<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Descriptive pharmaco-epidemiological study on the use of Symbicort® Turbuhaler® in the treatment of asthma in France and impact of a new treatment strategy on compliance and asthma control            </titl>
      <altTitl>
                    SYMBIOSE                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF188-en            </IDNo>
      <IDNo agency="PEF">
                    188                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF188                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Florence THOMAS-DELECOURT                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="ASTRAZENECA (FRANCE)">
        <ExtLink title="ROR" URI="https://ror.org/016qv5070" role="organisation id"/>
        <ExtLink title="SIREN" URI="558201075" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Pascal PIEDBOIS                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="GCS INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE (GCS ICANS)">
        <ExtLink title="ROR" URI="https://ror.org/008fdbn61" role="organisation id"/>
        <ExtLink title="SIREN" URI="794139246" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="" type="">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            ASTRAZENECA (FRANCE)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            ASTRAZENECA (FRANCE)                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="ASTRAZENECA (FRANCE)" email="florence.thomas@astrazeneca.com">
                    Florence;THOMAS-DELECOURT
                                            <ExtLink title="ROR" URI="https://ror.org/016qv5070" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="558201075" role="organisation id"/>
                                    </contact>
      <contact affiliation="GCS INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE (GCS ICANS)" email="pascal.piedbois@one2treat.com">
                    Pascal;PIEDBOIS
                                            <ExtLink title="ROR" URI="https://ror.org/008fdbn61" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="794139246" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    Symbicort® Turbuhaler®</keyword>
      <keyword vocab="" vocabURI="">
                    cohort</keyword>
      <topcClas vocab="health theme">
                        Pulmonary medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/f6e18c52-6087-4662-904c-5c4b8174e40e"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D015272"/>
                                                </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants: Use of care                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">Describe the characteristics of asthmatic patients treated with Symbicort Turbuhaler Compare the characteristics of patients treated according to the therapeutic strategy Evaluate the level of asthma control and compliance with treatment of patients treated with Symbicort Turbuhaler</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2009-01-01"/>
      <collDate event="end" date="2011-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Child (6 to 12 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002648"/>
                                                    </universe>
      <universe level="age" clusion="I">Young Adult (19 to 24 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D055815"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000368"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged, 80 and over (80 years and more)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000369"/>
                                                    </universe>
      <universe clusion="I">Patients diagnosed as asthmatic by the physician and treated for this pathology with Symbicort Turbuhaler                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity
Quality of life/health perception</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>[1000-10000[ individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Converting or copying information into a structured record                                                            <concept vocab="CESSDA" vocabURI="Transcription"/>
                                                    </collMode>
      <collMode>Interview with the participant (including clinical)                                                            <concept vocab="CESSDA" vocabURI="Interview"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <anlyInfo>
      <respRate>1844</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            To be defined                                                    </avlStatus>
    </setAvail>
  </dataAccs>
  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
</stdyDscr>
<dataDscr>
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